The Drosophila melanogaster ACE2 ortholog genes are differently expressed in obesity/diabetes and aging models: Implications for COVID-19 pathologyArticle Published on 2022-12-012022-11-15 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 ortholog ACE2 orthologs ACE2 receptor Acer age analyzed Ance animal model approach bind binding affinity complement coronavirus disease COVID-19 COVID-19 pathology COVID-19 severity death dependent on diabetes disorders Drosophila melanogaster Effect elderly ENhance expressed Factors glycoprotein host cells humans increase individual interact Interaction molecular molecular docking mRNA expression obesity ortholog predicted Protein regions regulated Research responsible risk factor Risk factors. robust SARS-CoV-2 SARS-CoV-2 variant shown spike spike-ACE2 susceptible the Spike translational Transmissibility virus [DOI] 10.1016/j.bbadis.2022.166551 PMC 바로가기
Whole-genome sequence analysis reveals the circulation of multiple SARS-CoV-2 variants of concern in Nairobi and neighboring counties, Kenya between March and July 2021Article Published on 2022-11-082022-11-16 Journal: Virology Journal [Category] SARS, 변종, [키워드] adaptive analysis analyzed B.1.1.7 B.1.351 B.1.617.2 Beta bioinformatics circulation community transmission comparison Coronaviruses COVID-19 COVID-19 cases Delta Epidemics genome sequence increase in Kenya Lineage majority Mutation Neutralizing antibodies Oxford Nanopore Technologies Phylogenetic Prevalence protocol reduced Region regions reveal RNA RT-PCR SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2. sequence Sequence analysis Sequencing Spread Strains study period the SARS-CoV-2 variant virulence virus virus transmissibility VoC was performed [DOI] 10.1186/s12985-022-01895-y PMC 바로가기
Retrospective analysis of SARS-CoV-2 omicron invasion over delta in French regions in 2021-22: a status-based multi-variant modelArticle Published on 2022-11-032022-11-16 Journal: BMC Infectious Diseases [Category] SARS, 변종, [키워드] affecting Analysis analysis approach average baseline level carried caused circulation conducted cross deaths disease epidemiological events expressed France French Generation time globe heterogeneity immunized incidence Invasion investigated knowledge Multi-variant model omicron outbreak parameter rapidly spreading disease Region regions replaced reported SARS-CoV-2 SARS-COV-2 infection Spread Transmissibility. transmission potential Uncertainty variant [DOI] 10.1186/s12879-022-07821-5 PMC 바로가기
Bioinformatics pipeline unveils genetic variability to synthetic vaccine design for Indian SARS-CoV-2 genomesArticle Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 치료기술, 치료제, [키워드] aligned amino acid change antigenic antigenic epitopes B-cell epitope bioinformatics bioinformatics pipeline can be used clade clades conserved conserved regions criteria epitope Evolution genetic variability genomic HLA allele identify immunogenic MAFFT MHC-I MHC-II Multiple sequence alignment Mutation Nextstrain Non-synonymous Non-Synonymous Signature SNP performed Phylogenetic analysis primer probe Protein Region regions reported resulting SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 pandemic selected SNP SNPs T-cell T-cell epitope T-cell epitopes T-cell epitopes. unique Vaccine Vaccine design virus virus detection virus genome [DOI] 10.1016/j.intimp.2022.109224 PMC 바로가기
Pandemic management requires exposure scienceArticle Published on 2022-11-012022-11-15 Journal: Environment international [Category] SARS, 치료기술, 치료제, [키워드] aerosol aerosol exposure applied Combination COVID-19 COVID-19 transmission effective Environmental and individual exposure control evaluated FFP2 and N95 respirators health care systems Infection Intervention less management Measures Misconception Non-pharmaceutical interventions North opportunity pandemic Pandemics pathway Personal protective equipment Protective public health authority reduce reduction regions risk reduction Spread suppress transmitted Vaccine Ventilation Ventilation and air cleaning Viral aerosol exposure prevention and reduction. virus WHO Wuhan, China [DOI] 10.1016/j.envint.2022.107470 PMC 바로가기
Type D lymphomatoid papulosis with pityriasis lichenoides et varioliformis acuta-like features in a child with parvovirus infection: a controversial diagnosis in the spectrum of lymphoid proliferations: case report and literature reviewArticle Published on 2022-10-282022-11-16 Journal: Italian Journal of Pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] Administered Alanine antigenic Aspartate aminotransferase Bilirubin C-reactive protein Case report CD8+/CD30+ cells children clinical response clinical suspicion Critical cytokine profile Cytokines Department Diagnosis differential diagnosis discharged disease disorder Emergency erythematous feature Fever histological history Hospitalized IFN-γ IL-10 IL-6 immunoglobulin M infectious agent infiltration introduced Laboratory test lesion lesions limits literature review lymphoid lymphomatoid Lymphomatoid papulosis lymphoproliferative Lymphoproliferative cutaneous disorders marker mechanism monoclonal morphologically necrotic Parvovirus parvovirus B19 pathogenic Perspective phenotype pityriasis lichenoides et varioliformis acuta. polymerase chain reaction positive response proliferation Rash recorded regions reported representing returned SARS-CoV-2 antigen separated skin lesions steroid Support Symptom systemic corticosteroid T-cell receptor Therapies Treatment Type Type D [DOI] 10.1186/s13052-022-01371-x PMC 바로가기
Emergence and Spread of the SARS-CoV-2 Variant of Concern Delta across Different Brazilian RegionsArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] affected analysis B.1.617.2 Bayesian method Brazil characteristic clade Cluster Combination Complete concern country COVID-19 COVID-19 pandemic Delta delta variant dissemination distribution dominant variant emergence Epidemic epidemiological Evolution fraction Genome genomic India likelihood Lineage outbreak pandemic Prevalence prevalent profiles Region regions remained Rio de Janeiro SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant spatiotemporal Stage subject Surveillance the SARS-CoV-2 transmission cluster variant Variant of concern. viral variant VoC [DOI] 10.1128/spectrum.02641-21 PMC 바로가기
Towards the development of an epitope-focused vaccine for SARS-CoV-2Article Published on 2022-10-262022-11-15 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies BALB/c mice CD8+ T cell COVID-19 deficiency disease DNA effective effort epitope expression hamster hamsters IFN-γ immunogenic immunogenicity data in vitro Inclusion mice Mortality pandemic coronavirus peptide peptides platform predicted prevalent Protein Proteins RBD peptide regions reported RNA Safe SARS-CoV-2 SARS-CoV-2 virus sequence specific IgG antibody spread of COVID-19 starting point subcutaneous administration Support tested the Spike Vaccine Vaccine development vaccine. Vaccines variant variants of concern Viral vector virus [DOI] 10.1016/j.vaccine.2022.09.059 PMC 바로가기
PrimedSherlock: a tool for rapid design of highly specific CRISPR-Cas12 crRNAsArticle Published on 2022-10-142022-11-15 Journal: BMC Bioinformatics [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] assays automated benefit bioinformatics Cas12 nuclease assay Cas12a Combination conserved CRISPR CRISPR-Ca CRISPR-Cas12 Critical demonstrated Dengue diagnostic diagnostics Efficiency facilitated FDA approval field Field forward diagnostics flavivirus genomes genomic HIV In-vitro Intensive isothermal isothermal amplification manual curation Nile nucleases nucleic acid offer parameter Pathogens platform polymorphism PrimedRPA PrimedSherlock primer primer pair Primers qRT-PCR regions RNA robust SARS-CoV-2 Serological assay serotype SHERLOCK significantly specificity strain Strains target targets Vector-borne disease West West Nile wildtype Zika Zika. [DOI] 10.1186/s12859-022-04968-5 PMC 바로가기
Do COVID-19 CT features vary between patients from within and outside mainland China? Findings from a meta-analysisArticle Published on 2022-10-142022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy Chest Chest computerized tomography Chest CT China clinician Cochrane Library consolidation coronavirus disease COVID-19 database Diagnosis diagnostic diagnostic value evaluate feature finding GGO ground-glass opacity incidence incidence rate lung involvement Meta-analysis meta-analysis Meta-analysis. nodule Patient performed Pneumonia Quality R software radiologist regions retrieved risk SARS-CoV-2 screened septal thickening significantly higher significantly lower the patient two group Vascular was used [DOI] 10.3389/fpubh.2022.939095 PMC 바로가기